Hence, the inhibition of such oxidation by zyloprim (allopurinol) may result in as much as a 75 reduction in the therapeutic dose requirement of mercaptopurine when the two compounds are given together. The occurrence of hypersensitivity reactions to zyloprim (allopurinol) may be increased in patients with decreased renal function receiving thiazides and zyloprim (allopurinol) concurrently. When the creatinine clearance is less than 10 mlmin, the daily dosage should not exceed 100 mg.
Zyloprim (allopurinol) , most of whom received concomitant drugs with the potential for causing this reaction. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. Patients may wish to take zyloprim (allopurinol) after meals to minimize you are encouraged to report negative side effects of prescription drugs to the fda.
They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of zyloprim (allopurinol) may be delayed for 2 to 6 weeks. There may be certain risks associated with the concomitant use of zyloprim (allopurinol) and dicumarol, sulfinpyrazone, mercap-topurine, azathioprine, ampicillin, amoxicillin, and thiazide diuretics, and they should follow the instructions of their physician. Reproductive studies have been performed in rats and rabbits at doses up to twenty times the usual human dose (5 mgkg per day), and it was concluded that there was no impaired fertility or harm to the due to allopurinol.
Renal failure is also frequently associated with gouty and rarely with hypersensitivity reactions associated with zyloprim (allopurinol). If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately. Xanthine crystalluria has been reported in only three patients.
Too much reliance should not be placed on a single serum uric acid determination since, for technical reasons, estimation of uric acid may be difficult. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. An analysis of current usage suggests that the incidence of acute gouty attacks has diminished to less than 1.
The renal clearance of hypoxanthine and xanthine is at least 10 times greater than that of uric acid. Some patients with the most severe reaction also had fever, chills, arthralgias, cholestatic. The use of colchicine or anti-inflammatory agents may be required to suppress gouty attacks in some cases. This is in contrast to the nullifying effect of salicylates on uricosuric drugs. Whereas zyloprim (allopurinol) is cleared essentially by glomerular filtration, oxipurinol is reabsorbed in the kidney tubules in a manner similar to the reabsorption of uric acid.
The clearance of oxipurinol is increased by uricosuric drugs, and as a consequence, the addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acid. This reaction involves a number of organs in the body and may be fatal if not treated quickly. The safety and effectiveness of allopurinol for this age group have not been established in treatment of other conditions. Zyloprim (allopurinol) is rarely indicated for use in children with the exception of those with hyperuricemia secondary to ) is 160 mgkg given intraperitoneally (ip) with deaths delayed up to 5 days and 700 mgkg orally (po) (approximately 140 times the usual human dose) with deaths delayed up to 3 days. By selecting the appropriate dosage and, in certain patients, using uricosuric agents concurrently, it is possible to reduce serum uric acid to normal or, if desired, to as low as 2 to 3 mgdl and keep it there indefinitely.
Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Chlorpropamides plasma half-life may be prolonged by zyloprim (allopurinol) , since zyloprim (allopurinol) and chlorpropamide may compete for excretion in the renal secondary to this mechanism may be increased if zyloprim (allopurinol) and chlorpropamide are given concomitantly in the presence of renal insufficiency. The correct dosage and schedule for maintaining the serum uric acid within the normal range is best determined by using the serum uric acid as an index. Renal failure is also frequently associated with gouty and rarely with hypersensitivity reactions associated with zyloprim (allopurinol). Renal failure in association with administration of zyloprim (allopurinol) has been observed among patients with and congestive myocardial disease were present among those patients whose renal dysfunction increased after zyloprim (allopurinol) was begun.
They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of zyloprim (allopurinol) may be delayed for 2 to 6 weeks. Since the effect of allopurinol on the nursing infant is unknown, caution should be exercised when zyloprim (allopurinol) is administered to a nursing woman. A fluid intake sufficient to yield a daily urinary output of at least 2 liters and the maintenance of a neutral or, preferably, slightly alkaline under the influence of therapy with zyloprim (allopurinol) and (2) help prevent renal precipitation of urates in patients receiving concomitant uricosuric agents. It is also used to reduce the levels of uric acid in the blood that occur because of blood disorders associated with cancer such as leukemias and lymphomas. The frequency of skin rash among patients receiving concurrently with zyloprim (allopurinol) has been reported to be increased (see early clinical studies and incidence rates from early clinical experience with zyloprim (allopurinol) suggested that these adverse reactions were found to occur at a rate of greater than 1. Past experience suggested that the most frequent event following the initiation of allopurinol treatment was an increase in acute attacks of (average 6 in early studies). If progressive deposition of urates is to be arrested or reversed, it is necessary to reduce the serum uric acid level below the saturation point to suppress urate precipitation. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects (see it has been reported that zyloprim (allopurinol) prolongs the half-life of the , dicumarol. The degree of this decrease can be manipulated almost at will since it is dose-dependent.Each white, round, biconvex, scored tablet ... over "100" on one side contains 100 mg of allopurinol.